ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models
نویسندگان
چکیده
منابع مشابه
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Water homeostasis in the brain is of central physiologic and clinical importance. Neuronal activity and ion water homeostasis are inextricably coupled. For example, the clearance of K+ from areas of high neuronal activity is associated with a concomitant water flux. Furthermore, cerebral edema, a final common pathway of numerous neurologic diseases, including stroke, may rapidly become life thr...
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متن کاملThe Transgenic Animal Models
Shortly after discovery of ET-1 in 1988, the entire endothelin system was characterized. The endothelin system consists of the three peptides ET-1, ET-2 and ET-3, their G-protein-coupled receptors endothelin receptor A and B (ETRA and ETRB) and the two endothelin-converting enzymes (ECE-1 and ECE-2). Genetically modified animal models are an important tool in biomedical research. Here we descri...
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ژورنال
عنوان ژورنال: Neurochemical Research
سال: 2018
ISSN: 0364-3190,1573-6903
DOI: 10.1007/s11064-018-2679-4